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Clenbuterol, a β2-sympathomimetic agent, is a synthetichormone with similar physiological functions to thecatecholamines, epinephrine and norepinephrine. Clenbuterolis one of a large group of compounds that are selective β2-adrenergic agonists. Other drugs in this class includealbuterol (salbutamol), pirbuterol and fenoterol. The Contaminants Working Group determined that clenbuterol is used in China, Mexico, and Guatemala as a growth promoter for cattle, lamb, poultry, and swine; that ractopamine is used in certain countries. Clenbuterol is a β2-adrenoceptor agonist. It is assigned a 3/B in the ARCI’s Uniform Classification of Foreign Substances. For Quarter Horse racing it is designated as a prohibited substance and assigned a Class A penalty. Clenbuterol Hydrochloride is a sympathomimetic that works on the sympathomimetic nervous system. There are several receptors in the body a sympathomimetic can act on. In the case of Clenbuterol, the beta-2 receptor is the area of interest and action. Clen, as it’s commonly known, actively stimulates the beta-2 receptor. Clenbuterol is a potent sympathomimetic drug that acts by binding with beta-2 adrenergic receptor. It has higher potency compared to other approved beta-2 agonists like salmeterol [ 1 ]. In addition to beta-2 selectivity, it also has an affinity to bind with beta 1 and beta 3 adrenoreceptor [ 2 ]. Furthermore, we were unable to confirm the reported correlations between AST, ALT, and bilirubin levels in response to oral administration of clenbuterol [70,71]
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